The Scientific Session will be held on Thursday September 14 from 8 a.m. to 5 p.m. The TDO User Meeting will take place on Friday September 15 from 8 a.m. to 5 p.m. and Saturday September 16 from 8 a.m. to 5 p.m. Breakfast will be served at 7 a.m. and lunch at noon on all days.
A reception, including dinner and entertainment, will be on Friday from 6:30 to 10 p.m. at the Paradise Point Resort. Please check the complete Schedule of Events for more details. For those interested, golf will be on Wednesday afternoon this year since the Scientific Session will be a full day on Thursday. The hotel offers a package to the Sycuan Resort which includes transportation. We thought an early afternoon tee time would allow travel time in the morning.
Dr. Gurol Suel received his PhD in Molecular Biophysics in 2003 and during his thesis work with Dr. Rama Ranganathan (UT Southwestern), he was part of a team that challenged the traditional view of protein function. Specifically, Dr. Suel applied a statistical thermodynamics approach to identify unknown allosteric regulation in many protein families. As a postdoc in the lab of Dr. Michael Elowitz (Caltech), he generated the first direct experimental evidence that molecular noise (randomness) can determine cell fate outcomes. After starting his independent laboratory in 2007, Dr. Suel continued to define a biological role for noise by integrating single cell measurements, synthetic biology and mathematical modeling. His laboratory then expanded its focus to study bacterial biofilm communities. The work uncovered a cell death pattern that emerges during biofilm development and determines colony morphology by channeling mechanical forces. His group used this insight to engineer the 3D organization of biofilms by controlling cell death. Dr. Suel’s group also developed a microfluidics method to study biofilm growth and uncovered oscillations driven by spatio-temporal coordination of metabolic states among distant cells. These collective oscillations were shown to increase the resilience of biofilms against chemical attack by resolving the social conflict between cooperation and competition among bacteria. Most recently, the Suel laboratory discovered a new form of bacterial communication that arises in biofilms: Ion channel mediated electrical cell-to-cell signaling. This finding revealed an unexpected connection between micro and neurobiology with many fundamental implications.
I will be presenting two lectures which relate two puzzling concepts in biology: The reality of disorder and randomness in biology, and how order and organization can arise from such disorder. Understanding these fundamental principles is essential to gain a clear understanding of bacterial biology and associated diseases.
The first lecture focuses on very basic yet far reaching questions with direct medical impact. Some of the questions we will explore are: Why do certain diseases appear to unexpectedly “pop” into existence? Why do not all cells respond in the same way to a given drug? Surprisingly, the answer to these questions turns out to be based on “chance events”, or more technically speaking stochasticity. In my lecture, I will discuss recent landmark findings that uncovered stochastic processes in biology. We will explore examples that show how chance events are in fact deeply rooted in the molecular interactions that underlie all biological processes. We will discuss examples ranging from development to microbial resistance to antibiotics. At the end of this lecture we will understand how and why cells sometimes “gamble” or “flip a coin” to make a decision.
In the second lecture we will discuss the poorly understood world of bacteria that reside in the context of biofilm communities. We will see that bacteria in biofilms can gain functions and behaviors that are only possible in the context of the collective, and have thus eluded scientists and even resulted in misunderstanding of antibiotic resilience. Among others, I will address the long-standing question regarding the native functional role of bacterial potassium ion channels, by showing that they serve an unexpected cell-to-cell signaling function in biofilms. Bacteria can thus achieve complex behaviors that are only possible through collective coordination of membrane potential. Therefore, numerous biomedically relevant bacterial processes that directly depend on the membrane potential, are likely to be governed by electrical signaling in biofilms, suggesting new research directions that could not have been envisioned prior to this discovery.
What attendees can expect to learn:
Dr. Eve Grodnitzky is a psychologist by training – and an author, executive educator and professional speaker by choice. After obtaining her Ph.D. in social psychology at the University of Michigan, she spent more than a decade working with several leading research and consulting firms, partnering with Fortune 500 and Global 1000 organizations on issues such as leadership development, performance management, employee engagement, and the attraction and retention of high-potential employees. For the past several years she has divided her time between delivering executive development sessions for various global clients and engaging in her own research initiatives related to the phenomenon of insight. Her new book, “CLICK: The Art + Science of Getting from Impasse to Insight,” details her seven-step methodology for facilitating and accelerating the insight-generation process. Much of Dr. Grodnitzky’s work with clients also includes the development of a “growth mindset.” A key focus of this work is helping people – from senior executives to front-line employees – shift from “the desire to prove how good they already are” to “the development of an obsession with learning, effort and improvement.” Dr. Grodnitzky’s work with clients has taken her to virtually every corner of the world, and in the course of delivering more than 1,000 speaking engagements over the years, she has had the privilege of working with organizations in 18 countries (and counting) on six continents. She is still trying to figure out how to arrange a session in Antarctica to make it a clean sweep of all seven. When she’s not on the road working with clients, Dr. Grodnitzky lives and works in the mountains west of Denver, Colorado with her husband and her Black Lab.
Mindset Changes Everything: The Art + Science of Success in Business and in Life
Why do some people embrace challenges, bounce back quickly from setbacks, take feedback well, and adapt easily to change – whereas others struggle to do these very same things? And (equally important) are these differences “hard-wired” – or are they something that we can change? The answer lies in an understanding of a concept called “mindset,” originally described by research psychologist Carol Dweck. Mindset is the most fundamental way that we perceive, understand, and interact with ourselves, other people, and the world at large – and it can take two different forms: “fixed” or “growth.” People with a fixed mindset believe that intelligence and skills are essentially innate (“fixed”) characteristics; you either have them, or you don’t. As a result, fixed mindset people often feel compelled to continually prove to themselves – and to others – how much innate intelligence and talent they already have. Unfortunately, this leads to a tendency to prefer working on things they’re already good at, and they can struggle if challenged to step outside their comfort zone – where they fear they might appear to be lacking in new or different skill sets. By contrast, people with a growth mindset believe that “innate” intelligence and skills are significantly less important than effort and learning. They believe that it’s not how you start – it’s how you finish. And how you finish is largely determined by how hard you’re willing to work and how much you’re willing to learn. As a result, people with a growth mindset are less concerned with proving how smart, talented, and capable they already are – and are more interested in doing everything they possibly can to get better. They embrace challenges, show resilience in the face of setbacks, welcome feedback, and are undaunted by change. The good news is that mindset itself is not “fixed”; it can be shaped at both the individual and the organizational level by focusing on three key factors. Understanding how to leverage these factors allows us to shift ourselves – and to help others shift – from fixed to growth mindset. Shifting to a growth mindset allows us – and our employees, our colleagues, our children and our partners – to perform at our best and to maximize our potential in every area of both our professional and
The Paradise Point Resort & Spa is located on Mission Bay and is approximately 6 miles from the San Diego International Airport (SAN). It is a full-service resort and spa with excellent features such as five pools, a private marina, mini golf course, fitness center, tennis courts and much more!
The room rate will be a discounted rate of $205 per night for the Lanai Garden Rooms. Click here or call (800) 344-2626 and reference “TDO Software” to make a reservation. In the Lanai Garden, you may choose one king or two queen beds. The deadline for this discounted rate is August 14th. Please do not delay in making your reservation–it is likely the hotel will sell out!
If the Paradise Point Resort & Spa is fully booked, the following three resorts are in closest proximity. Please note we do not have a group rate at these other resorts, but they may have rooms available.